|
KMID : 0359719920100040436
|
|
Journal of the Korean Neurological Association
1992 Volume.10 No. 4 p.436 ~ p.442
|
|
|
The Correlation between Anti-acetylcholine Receptor Antibody Titer and Clinical Grade in Myasthenia Gravis
|
|
|
|
|
Abstract
|
|
|
This study was performed to evaluate the titer of serum acetylcholine receptor antibody (AChR-Ab), the correlation between AChR-Ab titer and clinical state. Clinical response to thymectomy and histopathologic finding of thymus in myasthenia
gravis.
Twenty-seven patients with various clinical grades of myasthenia gravis and twenty-three normal controls were included in this study.
Mearl AChR-Ab titers were 4.21±4.27nM in myasthenia gravis and 0.05±0.06nM in control group (p<0.05). Mean AChR-Ab titers of each clinical grade were 0.80±1.67nM in grade I, 5.05±3.42nN in grade II a, 8.37±4.50nM in grade II b, 6.67nM in
grade
III
and 10.89nM in grade Ⅳ. There were significant correlation between clinical grade and level of AChR-AB titer. There were no correlation between degree of clinical improvement and changes of serum AChR-Ab titer after thymectomy in myasthenia
gravis.
There were also no correlation between level of AChR-Ab titers and histopathologic findings of thymus.
It is suggested that the assay of serum AChr-Ab is a useful test I diagnosis of myasthenia gravis and the titer of serum AChR-Ab can be an index of disease severity in myasthenia gravis.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|